中华临床免疫和变态反应杂志Issue(2)：91-95,5.DOI:10.3969/j.issn.1673-8705.2015.02.003
高频超声测量皮肤厚度在弥漫性系统性硬化症中的应用价值
Utility of High Frequency Ultrasound Measurement of Skin Thickness in Diffuse Cutaneous Systemic Sclerosis
刘赫 1朱庆莉 1侯勇 1徐东 2李梦涛 1姜玉新 2李建初 1曾小峰 2张奉春1
作者信息
- 1. 中国医学科学院 北京协和医学院 北京协和医院超声科，北京 100005
- 2. 中国医学科学院 北京协和医学院 北京协和医院风湿免疫科 风湿免疫病学教育部重点实验室，北京 100730
- 折叠
摘要
Abstract
Objective To investigate the utility of high frequency ultrasound measurement of skin thickness in diffuse cutaneous systemic sclerosis(dcSSc).Methods Twelve patients with dcSSc and 12 age and sex matched controls were recruited.The thickness of epidermis, dermis, and full skin (including both epidermis and dermis)were measured by high frequency ultrasound and the skin thickness was compared between dcSSc patients and healthy controls at 17 sites.The 17 sites were bilateral middle fingers,hand dorsum,forearms,upper arms,thigh,lower legs,foot dorsum,forehead,anterior chest,and anterior abdomen.The thickness of epidermis,dermis and full skin were compared between controls,clinical Rodnan skin score 0,1,2 and 3.Results The dermis of bilateral finger [right:0.600 (0.200)mm vs.0.500(0.200)mm;left:0.550(0.250)mm vs.0.500(0.100)mm],hand dorsum [right:1.200 (0.700)mm vs.0.500(0.200)mm;left:0.750(0.625)mm vs.0.500(0.175)mm],forearm [right:0.800(1.225 )mm vs.0.500 (0.175 )mm;left:0.650 (0.575 )mm vs.0.500 (0.200)mm],foot dorsum [right:0.750(0.65)mm vs.0.800(0.525)mm;left:0.550(0.625)mm vs.0.400(0.100) mm]and left upper arm [0.650(0.300)mm vs.0.500(0.100)mm]was thicker in dcSSc patients than controls.The full skin of bilateral finger [right:1.000(0.250)mm vs.0.800(0.275)mm;left:1.000 (0.400)mm vs.0.800(0.275)mm],hand dorsum [right:1.550(0.925)mm vs.0.800(0.275)mm;left:1.200(0.700 ) mm vs.0.800 (0.300 ) mm ], forearm [right: 1.150 (1.200 ) mm vs.0.800 (0.275)mm;left:1.250 (0.850 ) mm vs.0.800 (0.300 ) mm],and foot dorsum [right:1.200 (0.925)mm vs.1.150(0.450)mm;left:0.800(0.900)mm vs.0.700(0.200)mm]was thicker in dcSSc patients than controls.The epidermal,dermal,and full skin thickness were higher in clinical Rodnan score 1,2,3 than controls.The dermal and full skin thickness was higher in score 1,2 than 0.The epidermal thickness was higher in score 2 than 0. Conclusion High frequency ultrasound measurement of skin thickness is feasible and reliable for assessing the skin involvement in dcSSc.关键词
系统性硬化症/皮肤厚度/高频超声Key words
systemic sclerosis/skin thickness/high frequency ultrasound分类
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刘赫,朱庆莉,侯勇,徐东,李梦涛,姜玉新,李建初,曾小峰,张奉春..高频超声测量皮肤厚度在弥漫性系统性硬化症中的应用价值[J].中华临床免疫和变态反应杂志,2015,(2):91-95,5.
