中华脑科疾病与康复杂志（电子版）Issue(1)：43-46,4.DOI:10.3877/cma.j.issn.2095-123X.2014.01.011
脑动脉粥样硬化与肝细胞生长因子-转化生长因子-β1平衡关联性研究进展
Progression of research on the association between cerebral atherosclerosis and hepatocyte growth factor-transforming growth factor-beta 1 balance
摘要
Abstract
The main pathological development progresses of cerebral atheroslerosis are intracranial artery wall thickening,stiff,stenosis and occlusion,and ischemic cerebrovascular disease is the main clinical manifestations.In recent years,the high morbidity and high disability rate bring huge burden to patients, families and social medical resources.The numbers of intracranial vascular branch reducing have become the main pathogenic factor of vascular dementia.Hepatocyte growth factor (HGF )is one heparin affinity glycoprotein which is secreted from mesenchymal cells,has various biological activity functions as promoting cell proliferation,migration,differentiation,morphogenesis,anti-apoptosis.Its promoting angiogenesis has become a research hotspot.Transforming growth factor-beta 1 (TGF-β1 )is a cell signaling molecule which regulates the growth and differentiation of many cells,previous studies had indicated the presence of reciprocal balance relationship between TGF-β1 and HGF interaction,and the balance played an important role in maintaining homeostasis in normal body.This paper reviewed the related researches of the relationship between cerebral atherosclerosis and HGF-TGF-β1 balance,summarized the influence of maintaining the balance on the occurrence and development of intracranial atherosclerosis,and analyzed the future clinical feasibility of angiogenesis for treating ischemic cerebrovascular disease by exogenous HGF application.关键词
动脉粥样硬化/肝细胞生长因子/转化生长因子β1/血管新生Key words
Atherosclerosis/Hepatocyte growth factor/Transforming growth factor beta 1/Angiogenesis引用本文复制引用
申冠洋,宋志秀,常利,李彤..脑动脉粥样硬化与肝细胞生长因子-转化生长因子-β1平衡关联性研究进展[J].中华脑科疾病与康复杂志（电子版）,2014,(1):43-46,4.基金项目
河南省科技厅资助课题（112101310400）；河南省卫生厅资助课题 （）
