中华脑科疾病与康复杂志（电子版）Issue(2)：31-34,4.DOI:10.3877/cma.j.issn.2095-123X.2014.02.008
高血压合并高血脂建立脑动脉粥样硬化大鼠模型的实验研究
Experimental study of hypertension and high cholesterol building cerebral atherosclerosis rat model
摘要
Abstract
Objective Cerebral atherosclerosis ( CAS ) rat model established by hypertension and high cholesterol .Methods Twenty adult female Sprague-Dawley rats were equally randomized into model group(10 rats)and normal group(10 rats).Model group was made by bilateral renal artery stenosis and fed high fat diet for 16 weeks.While control group was made by renal artery dissection and fed basic food for 16 weeks.Blood pressure and blood lipid levels were measured before and after the experiment , while morphological changes of the internal carotid artery was observed by Hematoxylin-eosin( HE) staining.Data were analyzed by paired samples t test.Results Compared with the previous experiments ,the blood pressure (BP),total cholesterol(TC),total triglyceride(TG)and low-density lipoprotein-cholesterol(LDL-C)level of model group rats after operation had significantly higher than that before operation (tBP =10.665,tTC =26.357,tTG =11.121,tLDL-C =15.961,all P <0.05),high-density lipoprotein-cholesterol(HDL-C)had no significant difference(tHDL-C =0.173,P>0.05),The terminal segment of the internal carotid artery appear atherosclerotic plaques .Compared the previous experiments , the BP, TC, TG, LDL-C and HLD-C level of normal group rats after operation had no significant difference (tBP =1.182,tTC =0.654,tTG =1.202,tLDL-C =0.712,tHDL-C =1.462,all P>0.05),no vascular lesions.Conclusion CAS rat models are established by hypertension and high cholesterol ,the pathological changes similar to human ,stable and suitable for ischemic cerebrovascular disease research .关键词
高血压/高脂血症/肾动脉梗阻/动脉粥样硬化Key words
Hypertension/Hyperlipidemias/Renal artery obstruction/Atherosclerosis引用本文复制引用
朱岩岩,李彤,李合华,宋志秀,张平,闫海清,常利..高血压合并高血脂建立脑动脉粥样硬化大鼠模型的实验研究[J].中华脑科疾病与康复杂志（电子版）,2014,(2):31-34,4.基金项目
河南省科技厅资助课题（112101310400）；河南省卫生厅资助课题 （）
