中华脑科疾病与康复杂志（电子版）Issue(2)：58-61,4.DOI:10.3877/cma.j.issn.2095-123X.2014.02.015
MicroRNA-195调控肿瘤细胞生物学行为的研究进展
Recent advances on regulation of biological behavior mediated by microRNA-195 in malignant tumors
摘要
Abstract
MicroRNAs(miRNAs),which are approximately 22 nucleotides in length,are a class of endogenous, small, noncoding RNAs.MiRNAs can negatively regulate gene expression at the post-transcriptional and/or translational level by binding loosely complementary sequences in the 3′untranslated regions(UTR)of target mRNAs.It has been demonstrated that miRNAs regulate a wide range of biological processes,including embryonic development,angiogenesis,cell differentiation,proliferation and apoptosis. Growing evidences have indicated a strong association between miRNAs and cancers .MicroRNA-195 ( miR-195)is an important member of the miR-15a,15b,16,195,497 family,which plays an important role in the occur and development progress of tumors and regulation of malignant biological behaviours .Therefore , in-depth understanding of the mechanisms and roles of miR-195 on tumor development will provide a theoretical basis for clinical intervention of miRNA in tumor treatment .关键词
微RNAs/肿瘤/细胞增殖/细胞凋亡/肿瘤侵润/抗药性,肿瘤Key words
MicroRNAs/Neoplasms/Cell proliferation/Apoptosis/Neoplasm invasiveness/Drug resistance ,neoplasm引用本文复制引用
苗旺,张秀峰,杨欣,刘晓东,王宏勤,范益民..MicroRNA-195调控肿瘤细胞生物学行为的研究进展[J].中华脑科疾病与康复杂志（电子版）,2014,(2):58-61,4.基金项目
山西省基础研究计划青年科技研究基金（2012021035-4）；山西医科大学第一医院博士启动基金（YB1109）；山西省科技攻关项目 （）
