转化医学杂志Issue(3)：140-142,3.DOI:10.3969/j.issn.2095-3097.2014.03.004
催乳素水平与女性绝经前后乳腺癌的相关性研究
Study on the relationship between prolactin level and risk of breast cancer among pre-and postmenopausal women
摘要
Abstract
Objective To study the relationship between serum prolactin (PRL) levels and women breast cancer diagnosis .Method A total of 240 patients (breast cancer and breast benign hyperplasia) were recruited and divided into premenopausal breast cancer group ( RⅠ, 48 pa-tients), postmenopausal breast cancer group (RⅡ, 48 patients), premenopausal breast benign hy -perplasia group (ZⅠ, 88 patients) and postmenopausal breast benign hyperplasia group (ZⅡ, 56 patients).The electrochemical luminescence method was used to detect prolactin levels in peripheral venous blood serum.Results PRL level in group RⅠincreased obviously, and it was significantly higher than that of group RⅡ and group ZⅠ (P<0.001).The positive rate of PRL in group RⅠwas significantly higher than that of RⅡ and ZⅠ (P<0.001), but there was no significant diffe -rence between RⅡ and ZⅡ (P=0.776).The sensitivity (P<0.001) and accuracy (P=0.003) of PRL detection in premenopausal patients with breast cancer were higher than those in postmenopaus -al patients.Conclusion These results indicated that PRL contributed to the development of pre -menopausal breast cancer.Detection of serum PRL is helpful for early diagnosis and prevention of breast cancer in premenopausal women .关键词
乳腺癌/催乳素/血清标志物/绝经前期/绝经后期Key words
Breast cancer/Prolactin (PRL)/Serum marker/Pre-menopausal/Post-menopausal分类
医药卫生引用本文复制引用
翁雪芬,方裕森,黄旭纯,黄彬亮,庄珊珊,洪超群..催乳素水平与女性绝经前后乳腺癌的相关性研究[J].转化医学杂志,2014,(3):140-142,3.基金项目
广东省医学科研基金项目（ B2012261）；汕头市医疗重点科技计划项目 （）
