转化医学杂志Issue(3)：129-132,4.DOI:10.3969/j.issn.2095-3097.2015.03.001
基质金属蛋白酶及其抑制剂在颅内动脉瘤形成和发展过程中的作用
The rlo es of matrix metla loproteinase and its inhibitors in the formation and growth process of cerebral aneurysm
孔祥溢 1王任直1
作者信息
- 1. 100730 北京，中国医学科学院北京协和医学院北京协和医院神经外科
- 折叠
摘要
Abstract
Cerebral diseases is one of the commonest health hazards that severely threaten hu-man′s health, especially the aged more than 50 yrs old.And about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (CA).Therefore, exploring effective methods to de-crease CA′s incidence and reduce the effects of complications is of vital importance for maintaining-people′s health and extending the average human life span .It has been observed that the proteolytic activity , the expression of plasmin , membranetype-1 matrix metalloproteinase-1, and matrix metallo-proteinase-2 ( MMP-2) increased in aneurysm wall tissue that were all more than those in normal cerebral arteries .Moreover , MMP inhibitors such as doxycycline and statins may prohibit aneurysm formation and growth .MMP is involved in a lot of pathophysiology processes such as morphogenesis , angiogenesis , apoptosis and tissue repair .In this article , we reviewed the latest literatures and ex-plained in detail the roles of MMP and its inhibitors in the formation and growth process of CA .关键词
颅内动脉瘤/基质金属蛋白酶/基质金属蛋白酶抑制剂/多西环素Key words
Cerebral aneurysm/Matrix metalloproteinase ( MMP )/Matrix metalloproteinase inhibitors/Doxycycline分类
医药卫生引用本文复制引用
孔祥溢,王任直..基质金属蛋白酶及其抑制剂在颅内动脉瘤形成和发展过程中的作用[J].转化医学杂志,2015,(3):129-132,4.
