神经药理学报Issue(1)：1-11,11.
人参皂苷Rg1的抗抑郁作用及其作用机制
Antidepressive-like Effect of Ginsenoside Rg1 and Its Mechanism
摘要
Abstract
Objective:To investigate the anti-depressive-like effects and mechanisms of Ginsenoside Rg1. Methods:Antidepressant-like effect of Ginsenoside Rg1 was assessed in mice tail suspension test and forced swim test,and trat chronic unpredictable mild stress (CUMS)(28 days)test. Rg1(5,10,20 mg·kg-1·d-1)and duloxetine(10 mg·kg-1·d-1)were studied. Results:Rg1(5,10,20 mg·kg-1)significantly reduced the immobility time in both forced swimming and tail suspension tests. In animals receiving CUMS,they showed an increased immobility in the forced swimming test and decreased sucrose preference test,and Rg1 produced a significant decrease of immobility time and an increase of sucrose intake percentage. The anti-depressive-like mechanisms of Rg1 involved the activation of cAMP signal transduction pathways induced by PDE4,and the increase of androgens level as well as the promotion of the synaptogenesis. Conclusion:Ginsenoside Rg1 has robust antidepressant-like effects in acute and chronic models of depression,and the underlying mechanisms could involve regulating neurotransmitter release,reducing glucocorticoid levels and increasing the expression of neurotrophic factors as well as enhancing synaptic plasticity.关键词
抑郁/人参皂苷Rg1/急性应激/慢性温和不可预知性应激/糖皮质激素/突触可塑性Key words
depression/ginsenoside Rg1/acute stress/chronic unpredictable mild stress/glucocorticoid/synaptic plasticity分类
医药卫生引用本文复制引用
黄倩,楚世峰,连晓媛,张均田..人参皂苷Rg1的抗抑郁作用及其作用机制[J].神经药理学报,2013,(1):1-11,11.基金项目
国家自然科学基金资助项目 （）
