神经药理学报Issue(1)：23-27,5.
磷酸二酯酶-4：酒精依赖的潜在药物治疗靶点
Phosphodiesterase-4：the Potential Therapeutic Target for Alcohol Dependence
摘要
Abstract
Alcohol dependence is a psychiatric disease, which leads to serious individual and social harms. Latest advances in neurobiological research indicate the important role of cyclic adenosine monophosphate(cAMP)signal transduction in the development of alcohol drinking behavior. As a member of the phosphodiesterase(PDE)super family, PDE4 specifically catalyzes the hydrolysis of cAMP and represents a key point in regulating intracellular cAMP levels. Accumulating studies show that PDE4 inhibitors may be a novel class of pharmacotherapies for alcohol dependence. Here we review the existing evidence that support PDE4 as a novel theraputic target for alcohol dependence.关键词
酒精依赖/环腺苷酸/磷酸二酯酶-4/磷酸二酯酶-4抑制剂Key words
alcohol dependence/cAMP/phosphodiesterase-4(PDE4)/PDE4 inhibitor分类
医药卫生引用本文复制引用
文睿婷,张汉霆,梁建辉..磷酸二酯酶-4：酒精依赖的潜在药物治疗靶点[J].神经药理学报,2013,(1):23-27,5.基金项目
国家重点基础研究发展计划（973计划）项目（No.2009CB522003），国家自然科学基金项目（No.30870894），“十二五”国家科技支撑计划资助项目（No.2011BAK04B08），公安部重点研究计划项目 （）
