神经药理学报Issue(4)：39-46,8.
麻醉药作用机制及其保护作用与离子通道相关性研究进展
Anesthetic Mechanism, Its Protective Effect and Ion Channels
摘要
Abstract
Anesthetics have been widely used in clinical surgeries,but their detailed mechanisms are still unclear. With the application of some new techniques,it is found that the ion channels are involved in anesthetic mechanisms,such as the suppression of N-methyl-D-aspartate channel and neuronal nicotinic acetylcholine receptors,inhibition of opening the voltage-gated ion channels function,and enhancing the GABAA-R channels. In addition,the protective effects of anesthetics on organs are also related with ion channels,which can be realized via activating potassium channels,attenuating calcium influx and so on. This article reviews the relationship between the anesthetics and ion channels in these two aspects.关键词
麻醉药/γ-氨基丁酸受体通道/N-甲基-D-门冬氨酸受体通道/神经元烟碱乙酰胆碱受体通道/电压门控离子通道Key words
anesthetic/gamma aminobutyric acid receptor(GABAA-R) channel/N-methyl-D-aspartic acid(NMDA) receptor channel/neuronal nicotinic acetylcholine receptors(n-AChRs)/voltage-gated ion channel(VGIC)分类
医药卫生引用本文复制引用
李英杰,杨宝学..麻醉药作用机制及其保护作用与离子通道相关性研究进展[J].神经药理学报,2013,(4):39-46,8.基金项目
国家自然科学基金项目（No.30870921、No.81170632、No.81261160507），科技部国际科技合作与交流专项项目（No.2012DFA11070），教育部高等学校博士学科点专项科研基金项目 （）
