神经药理学报Issue(4)：58-64,7.
雌激素对阿尔茨海默病神经元保护作用研究进展
An Update on Neuroprotective Effects of Estrogen in Alzheimer’s Disease
摘要
Abstract
Alzheimer’s disease is a disease caused by a variety of CNS-degenerating factors,characterized by deposition of amyloid beta and hyperphosphorylation of tau protein. Estrogen can inhibit neuronal cell apoptosis by inhibiting the activity of caspase,regulating expression and the ratio of Bax and Bcl-2,increasing the content of cAMP in hypothalamic neurons and glial cells,promoting the rapid cAMP response element-binding protein (CREB) phosphorylation,influencing the N-methl-D-aspartate (NMDA) receptor expression in hippocampal cells. Estrogen also exerts direct protective effect on neuron cells by brain-derived neurotrophic factor and synaptophysin.关键词
雌激素/植物雌激素/阿尔茨海默病/神经元损伤Key words
estrogen/phytoestrogen/Alzheimer’s disease/neuronopathies分类
医药卫生引用本文复制引用
刘靓靓,沈丽霞..雌激素对阿尔茨海默病神经元保护作用研究进展[J].神经药理学报,2013,(4):58-64,7.基金项目
河北省自然科学基金资助项目（No.H2012405016），河北省教育厅资助项目（No.Z2013069），河北北方学院创新人才培育基金项目（No.CXRC1325），2013年度河北北方学院校级重大项目 （）
