神经药理学报Issue(1)：52-57,6.
大黄酚神经保护作用及其机制研究进展
Protective Effects and Mechanisms of Chrysophanol in the Nervous System
摘要
Abstract
Chrysophanol is an active component of the herbal medicine rhubarb (Rheum palmatum). Many researches have shown that chrysophanol has extensive bioactivity in cerebral ischemia-reperfusion injury and Alzheimer’s disease. The neuroprotective mechanisms include antioxidant, AChE activity inhibition, brain amino acid modulation, brain tissue hypoxia tolerance enhancement, hippocampal neuron damage protection and neuronal apoptosis inhibition. It is a compound with a broad application potential. This paper mainly discussed the protective effects and mechanisms of chrysophanol in the nervous system.关键词
大黄酚/抗氧化/脑缺血再灌注/神经元凋亡Key words
chrysophanol/antioxidant/cerebral ischemia-reperfusion/neuronal apoptosis分类
医药卫生引用本文复制引用
颜娟,张丹参..大黄酚神经保护作用及其机制研究进展[J].神经药理学报,2014,(1):52-57,6.基金项目
河北北方学院重大项目（No.ZD201310），河北省青年科学基金项目 （）
