针灸临床杂志Issue(8)：74-77,4.
电针对APP／PS1转基因 AD鼠 Morris水迷宫学习记忆及脑皮层Aβ水平的影响
Effect of Electro-acupuncture on Learning and Memory Behavior in Morris Water Maze and Cerebral Aβin APP/PS1 Transgenic AD Mice
摘要
Abstract
Objective:To explore the effect of electro -acupuncture on learning and memory behavior and the cerebral cortex Aβlevel in five months APP/PS1 transgenic AD mice .Methods:20 APP/PS1 transgenic posi-tive male mice were randomly divided into a model group and an electro -acupuncture group ,with 10 in each group .At the same time there were 10 APP/PS1 transgenic negative male mice in the normal control group .The electro-acupuncture group was acupunctured at“Baihui”and“Yongquan” ,then was adopted the intervention of electrical needle equipment which was dilatational wave , 15 min at a time ,every other day at a time ,treatment lasted five weeks .Finally the ability of learning and memory of all mice was tested by Morris water maze .Use immunohistochemical imaging to study the levels of cerebral Aβin mice.Results:Escape latency between three groups was statistically significant ( P<0 .05 );the difference between the model group and the electro -acu-puncture group was statistically significant (P<0.05).Expressions of Aβ1-40 and Aβ1-42 of the electro-acupuncture group were lower than those in the model group .Conclusion:Electro-acupuncture can probably improve learning and memory ability of APP/PS1 double transgenic mice through reducing the level of Aβ.关键词
电针/APP/PS1/Morris水迷宫/学习记忆/Aβ水平Key words
Electro-acupuncture/APP/PS1/Morris water maze/Learning and memory behavior/Aβ分类
医药卫生引用本文复制引用
白杨,薛卫国,高亮,陈默,辛随成..电针对APP／PS1转基因 AD鼠 Morris水迷宫学习记忆及脑皮层Aβ水平的影响[J].针灸临床杂志,2014,(8):74-77,4.基金项目
国家自然基金项目，编号81273826。 （）
