针灸临床杂志Issue(9)：52-54,3.
电针对糖尿病周围神经病大鼠坐骨神经 Nrg1和 ErbB2表达的影响
Effects of Electroacupuncture on the Expression of Nrg1 and ErbB2 in the Sciatic Nerve in Rats with Diabetic Peripheral Neuropathy
摘要
Abstract
Objective:To investigate the effects of electroacupuncture on the expression of Nrg1 and ErbB2 in the sciatic nerve of rats with diabetic peripheral neuropathy ( DPN) .Methods:The rats were randomly divided into a normal group,a model group,a common acupuncture group and an electroacupuncture group.The rat mod-els with diabetic peripheral neuropathy were established by streptozotocin peritoneal injection method.14 days after modeling, the blood sugar and conduction velocity of sciatic nerve were measured,and the mRNA expres-sions of Nrg1 and ErbB2 in the sciatic nerve were detected by RT-PCR.Results:14 days after modeling,com-pared with the normal group, the blood sugar of model group, acupuncture group and electroacupuncture group was increased (P<0.01).Compared with the model group, the conduction velocity of sciatic nerve was in-creased in common acupuncture group and electroacupuncture group ( P<0.01 ) , and mRNA expressions of Nrg1 and ErbB2 in sciatic nerve were increased ( P<0.01) .While it was improved more obviously in the elec-troacupuncture group than that in the common acupuncture group ( P<0.05) .Conclusion:Electroacupuncture could promote the nerve functional recovery of diabetic peripheral neuropathy by elevating Nrg1 and ErbB2 in sciatic nerve, and promote Schwann cells survival.关键词
电针/糖尿病周围神经病/神经调节蛋白1/表皮生长因子受体2Key words
Electroacupuncture/Diabetic peripheral neuropathy/Nrg1/ErbB2分类
医药卫生引用本文复制引用
王晓莉,覃建阳,尹昌浩,张忠敏..电针对糖尿病周围神经病大鼠坐骨神经 Nrg1和 ErbB2表达的影响[J].针灸临床杂志,2014,(9):52-54,3.基金项目
黑龙江省卫生厅科研课题，编号2011-304。 （）
