针灸临床杂志Issue(5)：61-64,4.
艾灸预处理大椎穴对发热大鼠血清IL－6的影响
Effect of Moxibustion Pretreatment at Dazhui Point on Serum IL-6 Content of Fever Rats
摘要
Abstract
Objective:To observe the effect of moxibustion pretreatment at Dazhui on fever rat models induced by yeast,and to reveal the defervescence mechanism of moxibustion and moxibustion pretreatment.Methods:Randomly select 8 rats from 40 Wistar rats as a blank group, and then randomly select other 8 rats for moxibus-tion pretreatment and make marks as a moxibustion pretreatment group.After moxibustion pretreatment, except the blank group, 20%dry yeast suspension was used respectively to 32 rats with subcutaneous injection.After the success of establishing the remaining, equally group qualified 24 rats into a model group, a moxibustion group and an Antondin group.Moxibustion group and moxibustion pretreatment group respectively were treated by moxibustion at Dazhui for 15 min, and the Antondin group was treated by intraperitoneal injection of An-tondin.Then measure the temperature before building models and after building 8 h and after treatment 1 h, 2 h, 3 h, 4 h.At the end of the experiment measure the serum IL-6 of each rat.Results:Compared with the model group,the moxibustion group,the Antondin group,the moxibustion pretreatment group had a significant difference ( P<0.01) .Compared with the moxibustion group,the Antondin group and the moxibustion pretreat-ment group had a significant difference ( P <0 .01 ) .The Antondin group and the moxibustion pretreatment group had no significant difference ( P>0 .05 ) , and compared with the blank group there was no significant difference ( P>0.05 ) .Conclusion:Moxibustion has certain antipyretic effect.The effect of moxibustion pre-treatment can reduce thermal potential.Its mechanism may be generated by inhibiting the serum IL-6 or its role, then reducing the influence of the temperature regulating center by endogenous pyrogens,to reduce temper-ature set-point up amplitude or return to normal, so as to reduce the thermal potential and have an antipyretic effect.关键词
艾灸/预处理/大椎/发热/IL-6/大鼠Key words
Moxibustion/Pretreatment/Dazhui/Fever/IL-6/Rats分类
医药卫生引用本文复制引用
贾坤平,孙忠人,尹洪娜,勇入琳,张建奇,侯二雷,吴磊..艾灸预处理大椎穴对发热大鼠血清IL－6的影响[J].针灸临床杂志,2015,(5):61-64,4.基金项目
校大学生创新基金（2012）。 （）
