针灸临床杂志Issue(6)：69-72,4.
电针上调皮肤切除伤小鼠创缘组织 eNOS的表达
Increasing Endothelial Nitric Oxide Synthase(eNOS) Expression in Skin Wound-healing Mice by Electro-acupuncture
摘要
Abstract
Objective:To investigate the effect of electroacupuncture treatment on wound-healing mice and expression of endothelial nitric oxide synthase( eNOS) in skin tissues.Methods:60 C57/BL6 mice were divided into two groups:a model control group and an electro-acupuncture treatment group.Each group was subdivi-ded into five time points:1 d,3 d,7 d,10 d,14 d(n=6).All mice were given skin excision injury model pro-cessing,and the electroacupuncture was used in the treatment group.Planimeter was used to measure the size of wounds.IHC and Real-time PCR were used to evaluate the expression of eNOS protein and mRNA.Results:The expressions of eNOS protein and mRNA in the electroacupuncture treatment group at each time point were increased significantly compared with those in the model control group (P<0.05).The rate of wound healing was increased in the electro-acupuncture treatment group(P<0.05).Conclusion:Electro-acupuncture pro-motes skin wound-healing.And its mechanism may be to increase expression of endothelial nitric oxide syn-thase ( eNOS) caused by electro-acupuncture treatment.关键词
电针/损伤修复/内皮型一氧化氮合酶/实验研究Key words
Electro-acupuncture/Wound-healing/Endothelial nitric oxide synthase/Experimental research分类
医药卫生引用本文复制引用
魏庆双,孙忠人,杨添淞,李佳,郭恒瑞,杨佳鹏..电针上调皮肤切除伤小鼠创缘组织 eNOS的表达[J].针灸临床杂志,2015,(6):69-72,4.基金项目
黑龙江省自然科学基金重点项目，编号ZD201315。 （）
