针灸临床杂志Issue(8)：62-64,3.
艾灸对胰腺癌裸鼠移植瘤DPC4、ki67表达的影响
Effect of Moxibustion on DPC4 and ki67 Expression of Pancreatic Carcinoma in Nude Mice
摘要
Abstract
Objective:To observe the efficacy of DPC4 and ki67 in the expression of pancreatic carcinoma in nude mice treated by moxibustion and explore the possible mechanism of antitumor through moxibustion.Meth-ods:16 nude mice were inoculated with BxPC-3 cells to construct pancreatic carcinoma xenograft models and were divided into a model group and a moxibustion group randomly.On the next day give mice moxibustion at Dazhui point.After the treatment for 14 days,the tumor tissues in nude mice were removed.Use immunohisto-chemical method to detect the protein expression of DPC4 and ki67 in tumor tissues.Results:Compared with the model group,the DPC4 expression was significantly higher and ki67 expression was lower (P<0.05).Con-clusion:Moxibustion has a significant inhibition on the growth of transplanted tumor and the mechanism may be related to the up-regulation of the expression level of DPC4 and down-regulation of the expression level of ki67 in tumor tissues.关键词
胰腺癌/麦粒灸/免疫组化/DPC4/Ki67Key words
Pancreatic carcinoma/Moxibustion/Immunohistochemistry/DPC4/ki67分类
医药卫生引用本文复制引用
仲丽丽,孙忠人..艾灸对胰腺癌裸鼠移植瘤DPC4、ki67表达的影响[J].针灸临床杂志,2015,(8):62-64,3.基金项目
国家自然科学基金资助项目，编号81173599；黑龙江省博士后资助课题项目，编号LBH－Z14196。 （）
