摘要
Abstract
Objective To investigate the expression and clinical significance of CD151 and integrinα3 in colorectal car-cinoma and its clinicopathological significance. Methods The expressions of CD151 and integrinα3 were examined by using immunohistochemistry in tissue sections from 40 cases of colonitis and 96 cases of colorectal carcinoma. Results The positive rates of CD151 in colonitis and colorectal carcinoma tissues were 0.0%(0/40) and 88.5%(85/96), respectively;in colorectal carci-noma with lymph node metastasis and those without lymph node metastasis were 100.0%(66/66) and 63.3%(19/30), respectively;in colorectal carcinoma with distant metastasis and those without distant metastasis were 100.0%(46/46) and 78.0%(39/50), re-spectively (al P<0.05). The positive rates of integrinα3 in colonitis and colorectal carcinoma tissue were 0.0%(0/40) and 87.5%(84/96), respectively;in colorectal carcinoma with lymph node metastasis and those without lymph node metastasis were 100.0%(66/66) and 60.0%(18/30), respectively;in colorectal carcinoma with distant metastasis and those withour distant metastasis were 100.0%(46/46) and 76.0%(38/50), respectively (al P<0.05). The expression of CD 151 and integrinα3 was not correlated with age, gender, tumor size, pathological types and differentiation of colorectal carcinoma (al P>0.05), while closely correlated with lymph node metastasis and distant metastasis. Conclusion Detection of CD151 and integrinα3 may be of value in diagnosis, prognosis and treatment monitoring of colorectal carcinoma.关键词
结肠癌/CD151/整合素α3/免疫组化法Key words
Colorectal carcinoma/CD151/Integrinα3/Immunohistochemistry
