浙江医学Issue(12)：1053-1055,1075,4.
吡格列酮对非酒精性脂肪肝大鼠肝脏氧化应激的影响
Effects of pioglitazone on oxidative stress in rats with non-alcoholic fatty liver disease
吴青红 1阮水良2
作者信息
- 1. 323800 庆元县中医院消化内科
- 2. 嘉兴市第二医院消化内科
- 折叠
摘要
Abstract
Objective To investigate the effects of pioglitazone on oxidative stress in rats with high fat diet- induced non- alcoholic fatty liver disease (NAFLD). Methods Thirty SD rats were randomly divided into normal group, model group and pioglitazone group (n=10 in each). NAFLS was induced by feeding of high- fat diet in rats of model and pioglitazone groups. Rats in pioglitazone group were gavaged with 10mg/kg of pioglitazone daily;rats in normal and model groups received an equal vol-ume of saline. Two rats from each group were sacrificed at the end of week 6 for pathological examination;and at the end of week 12 al rats were sacrificed. The histological examinations were performed, contents of malondialdehyde (MDA) and heme oxyge-nase- 1 (HO- 1) in liver were determined. Results Compared with model group, the degrees of hepatic steatosis and inflamma-tion were significantly al eviated and contents of MDA in liver were decreased in pioglitazone group(P<0.05). The liver HO- 1 lev-els were significantly higher in pioglitazone group than those in normal and model groups(P<0.05). Conclusion Pioglitazone can induce the expression of HO- 1 in liver, which is associated with its protective effect on oxidative stress and attenuation of non- alcoholic fatty liver disease in rats.关键词
吡格列酮/非酒精性脂肪性肝病/大鼠/氧应激/血红蛋白氧合酶Key words
Pioglitazone/Non- alcoholic fatty liver disease/Rats/Oxidative sress/Heme oxygenase- 1引用本文复制引用
吴青红,阮水良..吡格列酮对非酒精性脂肪肝大鼠肝脏氧化应激的影响[J].浙江医学,2014,(12):1053-1055,1075,4.
