浙江医学Issue(16)：1385-1389,5.
虎杖对肺纤维化大鼠肺组织中SOD、GSH、MDA的影响
Effect of Rhizoma Polygoni Cuspidati on SOD,GSH and MDA contents in lung tissue of rats with bleomycetin-induced pulmonary fi- brosis
李柏颖 1宋康 2夏永良 3杨珺超 2石亚杰4
作者信息
- 1. 310003 杭州市红十字会医院呼吸科
- 2. 浙江中医药大学附属第一医院呼吸科
- 3. 浙江中医药大学附属第一医院中医科
- 4. 杭州市中医院呼吸科
- 折叠
摘要
Abstract
Objective To evaluate the effects Rhizoma Polygoni Cuspidati on SOD,GSH and MDA contents in lung tissue of rats with bleomycetin- induced pulmonary fibrosis. Methods One hundred and twenty healthy male SD rats were randomly divided in to 5 groups. Pulmonary fibrosis model was induced by intratracheal infusion of 50.5mg/100g bleomycetin. Rats in model group (n=30) were instil ed with saline 5ml/d by gavage after bleomycetin was infused;rats in preventive group(n=30)were treated with liquid extract of Rhizoma Polygoni Cuspidati 2d before bleomycetin infused;rats in alveolitis group (n=20)and pul-monary fibrosis group (n=10) were treated with liquid extract of Rhizoma Polygoni Cuspidati 7d after bleomycetin infused;rats in control group (n=30) were instil ed with saline 5ml/d. Five rats in each group were sacrificed on d3,7,14,28,42 and 56, and lung samples were col ected. The contents of SOD,GSH and MDA in lung homogenate were assayed. Results The levels of SOD and GSH on d 3,7 and 14 were lower in model group than those in control group(P<0.05) and preventive group(P<0.05);the levels of MDA on d7 and 14 were higher in model group than those in control group and preventive group (P<0.05). Conclusion Liquid extract of Rhizoma Polygoni Cuspidati has anti- oxidant effects, which is associated with the al eviation of alveolitis pulmonary fi-brosis induced by bleomycetin in rats.关键词
流浸膏/虎杖/肺纤维化/自由基/超氧化物歧化酶/谷胱甘肽/丙二醛Key words
Liquid extract/Rhizoma polygoni cuspidati/Pulmonary fibrosis/Anti- oxidant/SOD/GSH/MDA引用本文复制引用
李柏颖,宋康,夏永良,杨珺超,石亚杰..虎杖对肺纤维化大鼠肺组织中SOD、GSH、MDA的影响[J].浙江医学,2014,(16):1385-1389,5.
