摘要
Abstract
Objective To assess the efficacy and safety of atorvastatin with different doses in elderly patients with acute coronary syndrome. Methods One hundred and sixty elderly patients with acute coronary syndrome were treated with atorvas-tatin of 20mg/d (group A, n=54), 40mg/d (group B, n=54) or 80mg/d (group C, n=54). Serum high sensitive C- reactive protein (hs- CRP), homocysteine(Hcy), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol(HDL- C), low density lipoprotein cholesterol(LDL- C) were measured before treatment and at week 4, 12 of treatment;and the alanine aminotransferase (ALT), creatinnine kinase (CK) and creatinine (Scr) levels were also measured before treatment and at week12 of treatment. Re-sults TC, LDL- C, TG levels after treatment in al 3 groups were lower than those before treatment (P<0.05 or 0.01). The HDL- C levels were higher at week12 of treatment than those before treatment in groups B and C (P<0.05). LDL- C level at week4 of treatment was lower in group B than that in group A (P<0.05);TC, LDL- C and TG levels at week4, 12 of treatment were lower in group C than those in group A (P<0.05 or 0.01). HDL- C at week12 of treatment in group C was higher than that in group A (P<0.05). The hs- CRP and Hcy levels in three groups were lower after treatment than those before treatment (P<0.05 or 0.01);hs- CRP and Hcy levels at week 4, 12 of treatment in groups B and C were lower than those in group A(P<0.05 or 0.01). ALT, CK, SCr levels were not significantly increased after treatment in al groups, and there were no significant differences in ALT, CK and SCr levels at week 12 of treatment among groups A, B and C (P>0.05). Conclusion Atorvastatin therapy at dose of 80mg/d is effective and safe for elderly patients with acute coronary syndrome.关键词
阿托伐他汀/急性冠状动脉综合征/超敏C反应蛋白/同型半胱氨酸/老年Key words
Atorvastatin/Acute coronary syndrome/High sensitivity C- reactive protein/Homocysteine/Elderly people
