Wnt信号通路的β- catenin和拮抗因子SFRP1在甲状腺乳头状癌中的表达及意义OACSTPCD
Expression of β-catenin and antagonist factor SFRP1 in papillary thyroid carcinoma and its clinicopathological significance
目的：探讨Wnt信号通路的β- catenin和拮抗因子SFRP1在甲状腺乳头状癌（PTC）中的表达及意义。方法采用免疫组化PV-8000法检测78例PTC组织和24例正常甲状腺组织中β- catenin和Wnt拮抗因子SFRP1蛋白的表达情况。结果 PTC组织中β- catenin阳性表达率明显高于正常甲状腺组织（P＜0.01），而Wnt拮抗因子SFRP1蛋白在PTC组织中阳性表达率明显低于正常甲状腺组织（P＜0.01）。β- catenin和…查看全部>>
Objective To investigate the expression of β- catenin of Wnt signaling pathway and its antagonist factor SFRP1 in papil ary thyroid carcinoma (PTC) and its clinicopathological significance. Methods The expression ofβ- catenin and SFRP1 was detected by immunohistochemical PV- 8000 method in 78 cases of papil ary thyroid carcinoma and 24 samples of normal thyroid tissue. Results β- catenin expression in PTC was significantly higher and SFRP1 expression was low…查看全部>>
章辉;曹学全;戴岳楚;卢洪胜
318000 台州市中心医院病理科318000 台州市中心医院病理科318000 台州市中心医院甲状腺乳腺外科318000 台州市中心医院病理科
甲状腺乳头状癌Wnt/β- cateninSFRP1
Papil ary thyroidCarcinoma β- cateninSFRP1
《浙江医学》 2014 (17)
1454-1456,3
评论