浙江医学Issue(19)：1601-1604,4.
血清软骨寡聚基质蛋白在幼年特发性关节炎中的临床意义
Serum cartilage oligomeric matrix protein in children with juvenile idiopathic arthritis and its clinical significance
摘要
Abstract
Objective To evaluate the clinical significance of serum cartilage oligomeric matrix protein in early prediction of joint damage with juvenile idiopathic arthritis (JIA). Methods Serum cartilage oligomeric matrix protein (COMP) levels were measured by enzyme linked immunosorbent assay (ELISA) in 35 children with juvenile idiopathic arthritis (JIA) in acute phase or remission stage and 30 children with inguinal hernia (control group). The correlation of serum COMP levels with clinical indicators of JIA patients was analyzed. Results Serum COMP level of JIA children in acute phase (0.77 ± 0.29ng/ml) was significantly lower than that of control group (1.33 ± 0.37 ng/ml, P<0.05). Serum COMP level of JIA children in acute phase was significantly lower than that in the recovery period (1.12 ± 0.28ng/ml, P<0.05). Serum COMP level of systemic JIA (0.26 ± 0.03 ng/ml) was significantly lower than that of oligoarticular JIA (0.87 ± 0.17 ng/ml), enthesitis- related arthritis JIA (0.89 ± 0.22 ng/ml) and pol-yarticular JIA (0.70 ± 0.35 ng/ml) (al P<0.05). The serum COMP levels of JIA with joint damage(0.52±0.22ng/ml)was signifi-cantly lower than those without joint destruction (0.92 ±0.22ng/ml, P<0.05). The serum COMP levels of JIA children in acute phase were negatively correlated with WBC, CRP, ESR (r=- 0.556,- 0.582,- 0.684, P<0.05), not correlated with joint pain index, swel ing index, morning stiffness, hemoglobin, platelet(r=0.06,- 0.206,- 0.107,- 0.319,- 0.185, P>0.05). Conclusion The lev-els of serum COMP are decreased in JIA with acute phase, systemic JIA and JIA with joint damage, and are negatively correlat-ed with inflammatory markers, indicating that serum COMP might be a useful predictor of JIA activity, joint destruction and growth inhibition.关键词
软骨寡聚基质蛋白/幼年特发性关节炎/关节破坏Key words
Cartilage oligomeric matrix protein/Juvenile idiopathic arthritis/Joint damage引用本文复制引用
钟世玲,吴菱,王天波,李蕴言,狄亚珍,林亚红..血清软骨寡聚基质蛋白在幼年特发性关节炎中的临床意义[J].浙江医学,2014,(19):1601-1604,4.基金项目
浙江省宁波市科技局科研项目（2010C50010）；浙江省宁波市卫生局科研项目 （）
