浙江医学Issue(19)：1605-1607,1625,4.
浙江省金华地区系统性红斑狼疮患者一级亲属抗核抗体谱检测及意义
Antinuclear antibodies levels in first-degree relatives of patients with systemic lupus erythematosus
摘要
Abstract
Objective To investigate the distribution of antinuclear antibodies level in first- degree relatives (FDR) of pa-tients with systemic lupus erythematosus (SLE). Methods Serum levels of antinuclear antibody and other autoantibodies were measured in 162 first- degree relatives of SLE patients and 80 healthy subjects in Jinhua region. Results Prevalence rate of SLE in first- degree relatives was 3.7%(6/162). Among remaining 152 non- SLE first- degree relatives, antinuclear antibody (ANA), anti- Ro52 antibody, anti- nucleosome, anti- Ro/SSA antibody, anti- nRNP antibody, anticardiolipin antibody (ACA)- IgG, ACA- IgM and anti- ds- DNA antibody were positive in 15 cases(9.8%), 8 cases (5.2%), 3 cases (2.0%), 6 cases (3.9%), 9 cas-es (5.9%), 11 cases(7.2%), 3 cases(2.0%), 12 cases(7.8%), respectively. Higher positive rate of ANA, (ACA)- IgG and an-ti- ds- DNA antibody were found in FDR of SLE patients than healthy control group (P<0.05). Conclusion The first- degree rel-atives of SLE patients have higher positive rate of ANA, (ACA)- IgG and anti- ds- DNA antibody, indicating high risk of SLE for FDRs.关键词
系统性红斑狼疮/一级亲属/自身抗体谱Key words
Systemic lupus erythematosus/First- degree Relatives/Antinuclear antibodies引用本文复制引用
王颖芳,杜红卫,吴红华,华丽,马大庆,谢素红,郑昭璟..浙江省金华地区系统性红斑狼疮患者一级亲属抗核抗体谱检测及意义[J].浙江医学,2014,(19):1605-1607,1625,4.基金项目
金华市科技研究计划项目 （）
