浙江医学Issue(20)：1696-1698,3.
卡介苗素对慢性阻塞性肺疾病患者细胞免疫功能的影响
Effect of BCG-PSN on cellular immune function in patients with chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the immunoregulatory activity of BCG- PSN in patients with chronic obstructive pul-monary disease (COPD). Methods Sixty COPD patients were randomly assigned to BCG group and control group with 30 in each. Conventional treatment was given to both groups, patients in BCG group also received BCG- PSN 0.35mg i.m, q.o.d for 3 months. Both groups were fol owed up for 6 months. The recurrence rate of COPD, the time of infection control were observed in two groups. Serum levels of IFN- γ, IL- 4 at 0, 3, 6 months after treatment were measured and lung function at 0, 6 months af-ter treatment was examined. Results There were no differences in cytokines levels and lung function before treatment between two groups (P>0.05). There was also no difference in serum IFN- γand IL- 4 levels 3 months after treatment (P>0.05), but the IFN- γ/IL- 4 ratio in BCG group was higher than that in control group (P<0.05). On 6 months after treatment, serum IL- 4 levels were lower in BCG group (P<0.05), there was no difference in IFN- γlevels between two groups (P>0.05);however, the IFN- γ/IL- 4 ratio in BCG group was higher than that in control group (P<0.05), and percentage of FEV1/predicted was higher(P<0.01). The recurrence rate of COPD was lower and the time of infection control was shorter in BCG group than those in control group (P<0.05). Conclusion BCG- PSN can enhance cellular immune function and improve the prognosis of pa-tients with COPD.关键词
卡介苗素/慢性阻塞性肺疾病/干扰素-γ/白细胞介素4Key words
BCG- PSN/Chronic obstructive pulmonary disease/Interferon- γ/Interleukin 4引用本文复制引用
姜国伟,臧敏,何绿苑,蔡岗丽,陈秀华,朱颖,吴冠仪..卡介苗素对慢性阻塞性肺疾病患者细胞免疫功能的影响[J].浙江医学,2014,(20):1696-1698,3.基金项目
浙江省中医药科学研究基金资助项目 （）
