浙江医学Issue(22)：1841-1843,3.
宫颈癌及宫颈上皮内瘤变MGMT基因甲基化及其相关性研究
Relationship between methylation of MGMT gene promoter and cervical carcinoma
摘要
Abstract
Objective To investigate the methylation status of MGMT gene promoter in cervical carcinoma and cervical intraepithelial neoplasia (CIN). Methods Methylation status of MGMT gene promoter was detected with methylation specific PCR (MSP) in cervical exfoliated cel s from patients with CINI (n=50), CINII (n=50), CINIII (n=50), cervical carcinoma (n=50) and non- cancer controls(n=20). Results The promoter methylation rates of MGMT were 82.0%(41/50), 24.0%(12/50), 50.0%(25/50) and 80.0%(40/50) in cervical carcinoma, CIN I, CINII and CINIII, while no methylation was detected in control group (P<0.05). The methylation of MGMT gene was correlated with the clinicopathological characteristics and tissue differentiation of cervical carcinoma (P<0.05). Conclusion The methylation of MGMT gene promoter region is associated with cervical carcinoma, which may be used as potential marker for early diagnosis of cervical carcinoma.关键词
宫颈癌/O6-甲基鸟嘌呤-DNA甲基转移酶/甲基化Key words
Cervical carcinoma/MGMT/Methylation引用本文复制引用
陆欢,陈莹蓉,孙立奇,陶志梅,张甦,邓再兴,戴利成..宫颈癌及宫颈上皮内瘤变MGMT基因甲基化及其相关性研究[J].浙江医学,2014,(22):1841-1843,3.基金项目
湖州市科技局自然资金课题 （）
