浙江医学Issue(24)：1997-1999,3.
浙南地区女性人群OPRM1基因多态性（rs1799971）与舒芬太尼自控镇痛效果的研究
Association between OPRM1 gene polymorphisms and effect of sufentanil in postoperative patient-controlled analgesia
诸光峰 1上官王宁 2张高娇3
作者信息
- 1. 325000 温州医科大学
- 2. 温州市中西医结合医院麻醉科
- 3. 温州医科大学附属第二医院麻醉科
- 折叠
摘要
Abstract
Objective To investigate the association between OPRM1 gene polymorphisms and efficacy of sufen-tanil in postoperative patient- control ed analgesia . Methods Two hundred patients undergoing hystermyoma received post-operative patient- control ed analgesia (PCA) with sufentanil from January 2010 to May 2012. Peripheral blood samples were col ected for DNA extraction. OPRM1 gene(rs1799971) polymorphisms were detected. The sufentanil consumption, the release time on analgesia, analgesic duration, VAS, and adverse reaction were documented and compared among different genotype groups. Results Genotyping analysis revealed that the genotype distribution of polymorphisms in OPRM1 gene was AA in 127 cases, AG in 62 cases, and GG in 11 cases. The frequency of OPRM1 mutation was 36.5%. The sufentanil consumption at 2h, 6h and 12h after surgery and VAS at 24h and 48h after surgery in GG group were higher than those in AG and AA groups (P<0.05). Conclusion The results indicate that OPRM1 gene polymorphism has the significant impact on analgesic efficacy of sufentanil.关键词
OPRM/基因多态性/舒芬太尼/自控镇痛Key words
μ- opioid receptor gene/Polymorphisms/Sufentanil/Postoperative analgesia引用本文复制引用
诸光峰,上官王宁,张高娇..浙南地区女性人群OPRM1基因多态性（rs1799971）与舒芬太尼自控镇痛效果的研究[J].浙江医学,2014,(24):1997-1999,3.
