浙江医学Issue(24)：2015-2017,2021,4.
双氯芬酸钠栓剂预防ERCP术后胰腺炎及高淀粉酶血症的临床研究
Diclofenac sodium suppository for prevention of post-ERCP pancreatitis and hyperamylasemia
摘要
Abstract
Objective To investigate the preventive effect of diclofenac sodium suppository for post- ERCP pancreatitis and hyperamylasemia. Methods A total of 240 patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) were randomly assigned to receive diclofenac sodium suppository (n=80), intravenous somatostatin (n=80), or no special medi-cation (n=80). The levels of serum amylase before ERCP and 4h, 24h after ERCP were measured, and the rate of acute pancre-atitis and hyperamylasemia after ERCP were assessed. Results Serum amylase levels before ERCP of three groups were al normal. The mean serum amylase levels in diclofenac group at 4h after ERCP were significantly lower than those in somatostatin and control groups (102.47 ±56.24U/L, 132.53 ±60.45U/L, 195.64 ±58.62U/L, respectively, both P<0.05). The mean serum amylase levels of diclofenac group (89.37±53.21U/L) and somatostatin group (95.79±54.87 U/L) 24h after ERCP were signifi-cantly lower than those of control group (186.83±56.35U/L, P<0.05), while there was no difference between diclofenac group and somatostatin group(P>0.05). The incidence of hyperamylasemia after ERCP in diclofenac group(6.25%) and somatostatin group (7.50%) was significantly lower than that of control group (18.75%, P<0.05), while there was no difference between di-clofenac group and somatostatin group(P>0.05). The incidence of post- ERCP pancreatitis in diclofenac group(2.50%) and so-matostatin group (3.75%) were significantly lower than that of control group (12.50%, P<0.05), while there was no difference be-tween diclofenac group and somatostatin group (P>0.05). Conclusion Diclofenac sodium suppository and somatostatin can effectively reduce the incidence of acute pancreatitis and hyperamylasemia after ERCP, and the former is more cheep and con-venient.关键词
双氯芬酸钠/ERCP术后胰腺炎/高淀粉酶血症/生长抑素Key words
Diclofenac/Post- ERCP pancreatitis/Hyperamylasemia/Somatostatin引用本文复制引用
丁全华,张优萍,李建阳..双氯芬酸钠栓剂预防ERCP术后胰腺炎及高淀粉酶血症的临床研究[J].浙江医学,2014,(24):2015-2017,2021,4.
