浙江医学Issue(3)：197-199,215,4.
神经生长因子转染的人脐带间充质干细胞促进中枢神经系统损伤修复的实验研究
Human umbilical cord mesenchymal stem cells transfected with nerve growth factor promote injury recovery of central nerves in rats
摘要
Abstract
Objective To investigate the effect of human umbilical cord mesenchymal stem cel s (hUC- MSCs) trans-fected with nerve growth factor (NGF) on injury recovery of central nerves in rats. Methods The isolated and cultured hUC- MSCs were transfected with adenovirus- mediated NGF gene. Ischemia hypoxia model of central nervous system was in-duced in Wistar rats. The NGF- transfected hUC- MSCs were transplanted in the model rats. The motion function of rats was eval-uated with footprint test and balance beam test. Results The transfected hUC- MSCs successful y expressed NGF protein. The footprint test and balance beam test showed that NGF- transfected hUC- MSCs promoted motor function recovery in rats with is-chemic injury of central nerves. Conclusion NGF- transfected hUC- MSCs can improve damage repair of central nerve in rats.关键词
人脐带间充质干细胞/神经生长因子/中枢神经损伤Key words
Human umbilical cord mesenchymal stem cells/Nerve growth factor/Central nerve damage引用本文复制引用
彭余江,李慧勇,何玺君..神经生长因子转染的人脐带间充质干细胞促进中枢神经系统损伤修复的实验研究[J].浙江医学,2015,(3):197-199,215,4.基金项目
浙江省温岭市科技计划项目 （）
