浙江医学Issue(3)：208-210,3.
c- Met蛋白在甲状腺癌中的表达及其临床病理意义
Expression of c-Met and its clinicopathological significance in thyroid carcinoma
摘要
Abstract
Objective To investigate the expression of c- Met protein in thyroid carcinoma and its clinicopathological significance in papil ary thyroid carcinoma. Methods The immunohistochemical En Vision method was used to evaluate the ex-pression of c- Met in 81 specimens of thyroid cancer tissues and 52 specimens of adjacent thyroid tissues. Results The ex-pression of c- Met protein in thyroid cancer was significantly higher than that in adjacent thyroid tissue (46.9%vs 7.7%, P<0.01). There were no significant differences in c- Met expression rates among papil ary carcinoma (50.8%, 31/61) , medul ary carcinoma (60.0%, 3/5) and fol icular carcinoma (26.7%, 4/15) (P>0.05). c- Met protein expression was not correlated with the clinicopatho-logical features of thyroid papil ary carcinoma (P>0.05). Conclusion c- Met expression is increased in thyroid cancer, it may be involved in the tumorigenesis of thyroid and might be a potential therapeutic target.关键词
c-Met/甲状腺癌/免疫组织化学Key words
C- Met/Thyroid cancer/Immunohistochemistry引用本文复制引用
王艳,王倩,赵永明,黄必飞,杜方民,董小芳,孙鑫鑫,邵俊康,王超群..c- Met蛋白在甲状腺癌中的表达及其临床病理意义[J].浙江医学,2015,(3):208-210,3.基金项目
浙江省医药卫生科技计划项目（2012KYB230）；浙江省金华市科技计划项目（2013-3-097）；浙江省金华市科技计划重点项目 （）
