浙江医学Issue(3)：211-215,5.
低钾血症对颅脑创伤患者预后的影响
Severe hypokalemia is a risk factor of mortality in patients with traumatic brain injury
吴建跃 1王卫民 1肖国民 1程军 1袁云鹏 1张眉 1丁皓俊 1姜启周1
作者信息
- 1. 310015 杭州师范大学附属医院神经外科
- 折叠
摘要
Abstract
Objective To investigate the prevalence of severe hypokalemia and outcome in traumatic brain injury (TBI) and its relation with outcome of patients. Methods One hundred and sixty eight TBI patients age≥18 yrs with hypokalemia ad-mitted between June 2010 and June 2013 were recruited in the study. Hypokalemia (<3.50mmol/L) was classified into 3 degrees of severity:mild (3.00mmol/L≤K+<3.50mmol/L), moderate (2.50mmol/L≤K+<3.00mmol/L) and severe(K+<2.50mmol/L). The minimal level of serum potassium during hospitalization was used for analysis. Hypernatremia and hypophosphatemia were de-fined as serum sodium>147.00mmol/L and serum phosphorus <0.80mmol/L in the blood. Results The mean level of lowest serum potassium for the 168 patients was 2.90mmol/L(1.10mmol/L~3.40mmol/L). TBI patients with severe hypokalemia had signif-icantly higher serum sodium and lower serum phosphorus than those patients with mild or moderate hypokalemia (P<0.01). The fatality rates in mild, moderate and severe hypokalemia groups were 10.5%, 25.7%and 82.1%, respectively (P<0.01). Multiple lo-gistic regression analysis revealed that decreased GCS (OR=1.28, 95%CI=1.12~1.42, P<0.01), low potassium level (OR=5.57, 95%CI=2.76~10.93, P<0.01), low phosphorus level (OR=2.76, 95%CI=1.11~7.25, P<0.01), and increased BUN (OR=1.16, 95%CI=1.07~1.24, P<0.01) were significantly associated with increased risk of mortality. Conclusion Our study demonstrates that TBI patients are likely to have hypokalemia;and severe hypokalemia and hypophosphatemia are the independent risk factors for mortality in TBI patients.关键词
重度低钾血症/颅脑创伤/高钠血症/低磷血症Key words
Severe hypokalemia/Traumatic brain injury/Hypernatremia/Hypophosphatemia引用本文复制引用
吴建跃,王卫民,肖国民,程军,袁云鹏,张眉,丁皓俊,姜启周..低钾血症对颅脑创伤患者预后的影响[J].浙江医学,2015,(3):211-215,5.
