浙江医学Issue(5)：363-366,4.
艾塞那肽对2型糖尿病大鼠糖脂代谢和胰岛超微结构的影响
摘要
Abstract
Objective To investigate the effects of glucagon- like peptide- 1 agonist exenatide on glucose and lipid metabolism and ultrastructure of islet cel s in type 2 diabetic rats. Methods Twenty- two male SD rats were randomly divided in-to non- diabetic control group (group C, n=6);non- diabetic+exenatide group (group C+E, n=6);diabetic group (group D, n=5) and diabetic+exenatide group (group D+E, n=5). Type 2 diabetes was induced by high- fat diet and low- dose streptozotocin in rats. The rats in C+E group and D+E group were treated with exenatide (5μg/d ) by subcutaneous injection, while the rats in C group and D group were injected with the same volume of normal saline. After 8 weeks, the body weight, fasting blood glucose, insulin, homeoestasis model assessment (HOMA- IR), insulin sensitivity index (ISI) and blood lipid profile were determined in al groups. The ultrastructure of islet cel s was observed with transmission electron microscopy. The one- way ANOVAs fol owed by a Student- Newman- Keuls post hoc test for multiple comparisons were used for statistics. Results Compared with group D, the fasting blood glucose, insulin, triglyceride, total cholesterol, lower density lipoprotein levels, and HOMA- IR were significantly de-creased (al P<0.05), while ISI significantly increased (P<0.05) in the D+E group. Electron microscopy observation revealed that exenatide attenuated the swol en mitochondria and endoplasmic reticulum in islet cel s of the diabetic rats. Conclusion The glucagon- like peptide- 1 agonist exenatide can significantly improve glucose and lipid metabolism and protect islet cel s in type 2 diabetic rats.关键词
糖尿病/胰高糖素样肽- 1受体激动剂/胰岛细胞/超微结构Key words
Diabetes/Glucagon like peptide 1 agonist/Islet cel s/Ultrastructure引用本文复制引用
吴晖,夏芳珍,华燕吟,陆颖理..艾塞那肽对2型糖尿病大鼠糖脂代谢和胰岛超微结构的影响[J].浙江医学,2015,(5):363-366,4.基金项目
浙江省中医药优秀青年人才基金项目 （）
