浙江医学Issue(9)：741-742,755,3.
上皮性卵巢癌患者 ERCC1 N118N基因型与铂类药物化疗敏感性关系的研究
Association of ERCC1 N118 N gene polymorphism with chemotherapy sensitivity in ovarian cancer patients with platinum-based chemotherapy
摘要
Abstract
Objective To investigate the association of ERCC1 N118 N gene polymorphism with chemotherapy sensi-tivity in epithelial ovarian cancer patients treated with platinum- based chemotherapy (taxol+ cisplatin, cyclophosphamide+cisplatin). Methods Ninety two patients with epithelial ovarian cancer treated with platinum- based chemotherapy were includ-ed in the study. Pre- treatment anticoagulated blood samples were col ected for extraction of genomic DNA. The TaqMan method was used to genotype single nucleotide polymorphisms (SNPs) in ERCC1 N118N gene. Results The genotype distribution at codon 118 was 57.6% with C/C and 42.4% with C/T+TT. Platinum- resistance was less frequently in patients with the C/T + T/T genotype (P=0.029). Conclusion ERCC1 N118 N gene polymorphism may be associated with chemotherapy sensitivity in ep-ithelial ovarian cancer patients treated with platinum- based chemotherapy.关键词
卵巢癌/核苷酸切除修复交叉互补基因1/基因多态性/药物敏感性Key words
Ovarian cancer/Excision repair cross- complementation gene 1/Polymorphism drug sensitivity/Chemotherapy sensitivity引用本文复制引用
夏婷,朱笕青,郑智国,杨悦..上皮性卵巢癌患者 ERCC1 N118N基因型与铂类药物化疗敏感性关系的研究[J].浙江医学,2015,(9):741-742,755,3.基金项目
浙江省自然科学基金资助项目 （）
