浙江医学Issue(12)：1055-1057,1060,4.
度洛西汀与帕罗西汀治疗首发抑郁症疗效及对性功能影响的研究
Therapeutic efficacy and effect on sexual function in treatment of first episode depression：a comparison between duloxetine and paroxetine
摘要
Abstract
Objective To compare the efficacy and effect on sexual function of duloxitine and paroxetine in treatment of first episode depression. Methods Seventy two patients with first episode depression were randomly assigned to receive duloxetine(n=36) or paroxetine(n=36) treatment for 8 weeks. The efficacy, sexual function and adverse effects were evaluated by Hamilton Rating Scale for Depression- 17 Items (HAMD17), scores of Arizona sexual experience scale (ASEX) and Treatment E-mergent Symptom Scale(TESS), Results The remission and response rates were 51.4%and 80.0%respectively in the duloxe-tine group and 47.1%, 76.5%in paroxetine group at the end of week 8 with no statistical difference between two groups. Scores of HAMD17 in duloxetine group was significantly lower than those in paroxetine group at the end of the first week. There were no significant differences between two groups in efficacy at the end of week 2, 4, 8. ASEX scores were significantly lower in duloxi-tine group than those in paroxitine group at the end of the 2nd, 4th, and 8th week. The incidences of adverse effects were 42.9%in duloxetine and 44.1%in the paroxetine group (P>0.05). Conclusion Duloxetine is effective and safe as paroxetine but takes effects faster at week 1. Duloxetine is more likely to improve sexual dysfunction or less to induce sexual dysfunction than paroxi-tine for patients with first episode depression.关键词
度洛西汀/帕罗西汀/首发抑郁症/性功能Key words
Duloxetine/Paroxetine/First episode of depression/Sexual function引用本文复制引用
费锦锋,戴红,吴杰,钱敏才,沈鑫华..度洛西汀与帕罗西汀治疗首发抑郁症疗效及对性功能影响的研究[J].浙江医学,2015,(12):1055-1057,1060,4.基金项目
湖州市科技攻关计划项目 （）
