浙江医学Issue(12)：1061-1064,1067,5.
青少年双相障碍Ⅱ型和单相抑郁的认知功能比较研究
Cognitive function in adolescents with bipolar disorder-Ⅱ or unipolar depression
摘要
Abstract
Objective To compare the cognitive function in adolescents with bipolar disorder- Ⅱ and those with u-nipolar depression. Methods Fifty four adolescents with bipolar disorder- Ⅱ (bipolar group), 83 adolescents with unipolar de-pression (unipolar group) and 50 healthy adolescents (control) were enrol ed in the study. Wechsler Adult Intel igence Scale (WAIS- RC), Trail Making Test(TMT), Continuous Performance Test (CPT), Wechsler Memory Scale(WMS- RC), Verbal Fluency(VF) and Wisconsin Card Sorting Test (WCST) were performed in al subjects, the tests were performed again after 6 weeks of treat-ment and patients experienced remission(HAMD≤7), Results Before treatment the TMT- A, WAIS- RC numerical symbols, CPT, WAIS- RC digit span subtest, WAIS- RC visual reproduction, VF, WCST and TMT- B scores in patients were worse than those in healthy controls (P<0.01). However, there were no significant differences between bipolar and unipolar groups (P>0.05). After six- week treatment, there was stil significant difference in WAIS- RC numerical symbols and WAIS- RC visual reproduction be-tween patients and healthy groups(P<0.05). The bipolar patients had difficulty in CPT, compared to healthy group(P<0.05), while the abilities of VF and TMT- B in unipolar patients were stil lower compared to healthy group(P<0.05). Conclusion The cognitive function in adolescents with bipolar disorder- Ⅱ or unipolar depression is general y damaged. At the remission of the disease bipolar patients have difficulty in sustained attention, while unipolar patients show the decline of executive function.关键词
双相障碍Ⅱ型/单相抑郁症/认知功能/持续性注意/执行功能Key words
Bipolar disorder- Ⅱ/Unipolar depressionl/Cognitive function/Sustained attention/Executive function引用本文复制引用
汤义平,陈倩倩,陆强,姜义彬,许学明,曹敏敏,蔡志杰,王筱芳..青少年双相障碍Ⅱ型和单相抑郁的认知功能比较研究[J].浙江医学,2015,(12):1061-1064,1067,5.基金项目
浙江省医学会临床科研基金项目 （）
