肿瘤药学Issue(4)：258-262,5.DOI:10.3969/j.issn.2095-1264.2014.052
肾癌组织中MMP-26的表达与其分化程度的相关性分析
Correlative Analysis of the MMP-26 Expression in Kidney Cancer with its Differentiation Degree
摘要
Abstract
Objective To investigate the expression of matrix metalloproteinases-26 (MMP-26) in renal carcinoma tissue, and to probe its relationship with the differentiated degrees of renal carcinoma tissue. Methods Immunohistochemistry method (ABC) was used to detect the MMP-26 expression of 60 cases of renal carcinoma tissues in different differentiated degrees and 20 cases of benign lesion tissues. Reverse transcription polymerase chain reaction (RT-PCR) was applied to detect the mRNA expression of 20 cases of surgical fresh tissues with renal carcinoma and 10 cases of benign lesion tissues. Results The positive expression rate of MMP-26 was 80%in renal carcinoma pathological tissues, but was 50%in benign renal pathological tissues (P<0.05). The positive expression rate of MMP-26 was 88.5%, 89.5%and 53.3%respectively in G1, G2 and G3 differentiation degree;It was statistically lower in G3 than in G1 and G2 (P<0.05), but its difference between G1 and G2 was of no significance (P>0.05). The mRNA expression of MMP-26 was (0.83±0.126) in renal carcinoma tissues, and (0.60±0.035) in benign le-sion tissues (P<0.05). The mRNA expression of MMP-26 was respectively (1.13±0.104), (0.90±0.072) and (0.80±0.031) in G1, G2 and G3 of renal carcinoma tissues;Difference between each two groups had statistical significance (P<0.05). Conclusion MMP-26 was highly expressed in renal carcinoma, and negatively correlated with the differentiation degrees of renal carcinoma.It would serve as an important indicator for evaluating severity and prognosis of renal carcinoma.关键词
肾癌/基质金属蛋白酶26/表达/分化Key words
Renal carcinoma/Matrix metalloproteinases-26/Expression/Differentiation分类
医药卫生引用本文复制引用
曲桂霞,扈青云,辛华,江清林..肾癌组织中MMP-26的表达与其分化程度的相关性分析[J].肿瘤药学,2014,(4):258-262,5.基金项目
黑龙江省教育厅科学技术研究项目（12533073）。 （）
