肿瘤药学Issue(5)：328-331,4.DOI:10.3969/j.issn.2095-1264.2014.067
姜黄素抗肿瘤作用机制的研究进展
The Research Progress of Curcumin Antitumor Mechanism
黄果 1王佑权 1谭米多 1谢海辉 1李伟 1刘国文1
作者信息
- 1. 南华大学第二临床学院，湖南 衡阳，421001
- 折叠
摘要
Abstract
A variety of tumor cells have expression of the inhibitor of apoptosis proteins (IAPs) such as survivin, NAIP, XIAP and Livin protein, as well as expression of resistance-to-apoptosis Bcl-2 family protein. The apoptosis inhibition mediated by IAPS may be one of the reasons for drug-resistant tumor cell and its survival. The Bcl-2 family proteins also play a role in anti-tumor apoptosis and promote their apoptosis proteins. Curcumin has functions like anti-inflammatory, antioxidant, inhibition of angiogenesis and so on. It can promote cell apoptosis and strengthen the antitumor effects through its regulation of protein expressions and related signaling pathways.关键词
姜黄素/IAPS/Bcl-2家族蛋白/信号通路/癌细胞/细胞凋亡Key words
Curcumin/IAPS/Bcl-2 family proteins/Signaling pathway/Cell apoptosis分类
医药卫生引用本文复制引用
黄果,王佑权,谭米多,谢海辉,李伟,刘国文..姜黄素抗肿瘤作用机制的研究进展[J].肿瘤药学,2014,(5):328-331,4.
