肿瘤药学Issue(5)：346-349,4.DOI:10.3969/j.issn.2095-1264.2014.071
雷替曲塞联合奥沙利铂方案与XELOX方案治疗晚期结直肠癌的对比研究
A Comparative Study on Raltitrexed plus Oxaliplatin Regimen and XELOX Regimen on the Treatment of Advanced Colorectal Cancer
潘登 1陈可和 1冯国生 1吴莹莹 1黄景宁1
作者信息
- 1. 广西壮族自治区人民医院临床肿瘤中心，广西 南宁，530021
- 折叠
摘要
Abstract
Objective To compare the clinical efficacy and safety of raltitrexed plus oxaliplatin program and XELOX regimen for patients with advanced colorectal cancer, and provide more evidences for the clinical treatment of colorec-tal cancer. Methods A total of 79 patients with advanced colorectal cancer admitted in the chemotherapy ward of clinical oncology center in our hospital were selected and randomly divided into the study group (39 cases) and control group (40 cases) according to different therapeutic regimens. The study group was treated by raltitrexed plus oxaliplatin regimen, while the control group was given XELOX regimen. A treatment cycle included 21 days. The clinical efficacy and inci-dence of adverse reactions such as vomiting, loss of appetite and so on were observed and compared between the two groups. Results There were respectively 32 cases and 30 cases in the study group and control group whose clinical efficacy could be evaluated, with a respective clinical efficacy of 53.13%and 50.0%. The median time to progression was 8.1 months in the study group and 8.9 months in the control group. No significant differences were found in the clinical efficacy between the two groups (P>0.05). The incidence rate of hematologic toxicity of the study group such as neutropenia was higher than that of the control group, and difference was statistically significant (P<0.05). The incidence rates of other adverse reactions such as hand-foot syndrome and diarrhea were significantly lower than those of the control group (P<0.05). Conclusion Raltitrexed combined with oxaliplatin regimen for patients with advanced colorectal cancer had equivalent clinical efficacy of XELOX regimen, but it is more secure and more convenient in medication.关键词
雷替曲塞/奥沙利铂/XELOX方案/晚期结直肠癌Key words
Raltitrexed/Aisha Leigh Per/XELOX scheme/Advanced colorectal cancer分类
医药卫生引用本文复制引用
潘登,陈可和,冯国生,吴莹莹,黄景宁..雷替曲塞联合奥沙利铂方案与XELOX方案治疗晚期结直肠癌的对比研究[J].肿瘤药学,2014,(5):346-349,4.
