肿瘤药学Issue(5)：374-378,5.DOI:10.3969/j.issn.2095-1264.2014.077
单纯放疗及同期放化疗治疗中晚期鼻咽癌的临床对比研究
A Comparative Study on the Clinical Effects of Simple Radiotherapy and Concurrent Chemoradiotherapv on Middle and Advanced Nasopharyngeal Carcinoma
肖庆成 1沈康 1卢晓艳 1付成磊1
作者信息
- 1. 泗阳县人民医院肿瘤科，江苏 宿迁，223700
- 折叠
摘要
Abstract
Objective To investigate the clinical effects and safety of radiotherapy and concurrent chemotherapy for patients with advanced nasopharyngeal carcinoma. Methods A retrospective analysis were carried out on the clinical data of 120 cases of advanced nasopharyngeal carcinoma patients in our hospital. According to the different treating ways, they were divided into four groups:group A with radiotherapy alone, group B with radiotherapy and concomitant paclitaxel chemotherapy, group C with radiotherapy and concomitant tegafur chemotherapy, group D with radiotherapy plus paclitaxel and tegafur chemotherapy. Each group had 30 patients. We observed and compared the therapeutic group's total effective rate, 5-year overall survival rate and adverse reaction during the treatment situation. Results The total effective rate and 5-year overall survival rate in group B, C, D were significantly higher than those in group A. The incidence of toxic reactions of group A was significantly lower than that of group B, C, D during the same period, and that of group B and C was also significantly lower than that of group D (P<0.05) but there were no significant differences between the group B and C (P>0.05). Conclusion Radiotherapy plus concurrent chemotherapy had better clinical effect for advanced nasopharyngeal carcinoma patients than radiotherapy alone. The radio-therapy plus single-drug chemotherapy had equal clinical effects with the radiotherapy plus combined-drug chemotherapy, but the former had better security and thus was worthy of clinical application.关键词
中晚期鼻咽癌/放疗/同期放化疗/临床效果Key words
Advanced nasopharyngeal carcinoma/Radiotherapy/Chemotherapy/Clinical effect分类
医药卫生引用本文复制引用
肖庆成,沈康,卢晓艳,付成磊..单纯放疗及同期放化疗治疗中晚期鼻咽癌的临床对比研究[J].肿瘤药学,2014,(5):374-378,5.
