摘要
Abstract
Objective To investigate the effects of Lobaplatin on the radiosensitivity of human cervical carcinoma and its mechanisms. Methods Hela cells cultured invitro were assigned to the blank group, low concentration Lobaplatin group, high concentration Lobaplatin group, blank+radiation group, low concentration Lobaplatin+radiation group and high con-centration Lobaplatin+radiation group, single light 6 Gy. Flow cytometry was applied to detect the cell apoptosis and cell cycle. Results Lobaplatin had inhibition on the growth of cervical cancer Hela cells. The Do numericals of the blank group, low concentration Lobaplatin group and high concentration Lobaplatin group were 1.76, 1.42 and 0.86 Gy (F=4006.0, P=0.00) respectively, the Dq numericals were 1.99, 1.37 and 0.92 Gy (F=3087.0, P=0.00) respectively, theαnumericals were 0.085, 0.254 and 0.262 Gy-1 (F=614.6, P=0.00) respectively, theβnumericals were 0.0652, 0.181 and 0.234 Gy-2 (F=1342.1, P=0.00) respectively. The cell apoptosis rates of the above six groups were respectively (1.10±0.01)%、(1.01 ±.006)%、(2.32±0.03)%、(2.87±0.008)%、(2.96±0.02)%、(4.38±0.01)%(F=23.1, P=0.00) . Lobaplatin could block cells in G2/M phase. Conclusion Lobaplatin could intensify the radiosensitivity of human cervical carcinoma cell, through enhancing the apoptosis.关键词
宫颈癌/放射敏感性/洛铂/细胞凋亡Key words
Cervical carcinoma/Radiosensitivity/Lobaplatin/Cell apoptosis分类
医药卫生
