肿瘤药学Issue(1)：38-41,4.DOI:10.3969/j.issn.2095-1264.2015.006
多西紫杉醇联合FOLFOX改良方案治疗晚期胃癌的临床疗效
The Clinical Efficacy of Docetaxel Combined with Modified FOLFOX Regimen in the Treatment of Advanced Gastric Cancer
周冬梅 1曹桂侠 1程朝晖 1姬海宁 1傅薇薇1
作者信息
- 1. 新沂市人民医院肿瘤内科，江苏新沂，221400
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy of docetaxel combined with FOLFOX improvement plan (oxalipl-atin+calcium+folinate+tegafur) in the treatment of advanced gastric cancer. Methods Eighty cases of patients with ad-vanced gastric carcinoma who couldn’t get resection operation or had postoperative recurrence and metastasis were selected and randomly divided into the experimental group (40 cases) and control group (40 cases). The experimental group received docetaxel+modified FOLFOX regimen chemotherapy, while the control group was given FOLFOX chemotherapy alone. After two cycles’treatment, the curative effect and incidence of adverse reactions were evaluated and compared between the two groups. Results For the experimental group, no complete remission (CR) case was observed, and partial remission (PR) was observed in 18 cases, stable disease (SD) in 12 cases, progressive disease (PD) in 10 cases. The clinical benefit rate (CR+PR+SD) was 75%, and the progression free survival (PFS) was 7 months. For the control group, PR was observed in 14 cases, SD in 13 cases, PD in 13 cases. The clinical benefit rate was 67.5%, and the PFS was 5.5 months. No statisti-cally significant difference was found in the clinical benefit rate between the two groups (P>0.05), but the PFS of experi-ment group was significantly longer than that of the control group (P<0.05). Bone marrow suppression was the main toxicity in both groups, but its incidence had no significant difference between the two groups (P>0.05). Conclusion Docetaxel combined with modified FOLFOX regimen was effective in treating patients with advanced gastric cancer, and its toxicities were tolerable.关键词
多西紫杉醇/FOLFOX改良方案/FOLFOX方案/晚期胃癌/疗效Key words
Docetaxel/ImprovedFOLFOXschemes/FOLFOX/Advancedgastriccancer/Efficacy分类
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周冬梅,曹桂侠,程朝晖,姬海宁,傅薇薇..多西紫杉醇联合FOLFOX改良方案治疗晚期胃癌的临床疗效[J].肿瘤药学,2015,(1):38-41,4.
