肿瘤药学Issue(2)：87-91,5.DOI:10.3969/j.issn.2095-1264.2015.017
人附睾蛋白4（HE4）在恶性肿瘤中的表达与临床进展
Expression of Human Epididymis Protein 4 in Cancer and its Clinical Progress
摘要
Abstract
Human epididymis protein 4 (HE4) is one member of the protease inhibitor family which have the immune protective effect. It can be detected in serum and tissues, presenting low expression in normal tissues but over expression in tumor tissues. Nowadays, numerous studies showed that HE4 has relationship with ovarian cancer, endometrial cancer, lung cancer and bladder cancer, etc. Besides, since it has a higher sensitivity and specificity than CA125, HE4 has been ap-proved by FDA as a new tumor marker for diagnosis of ovarian cancer in early stage. In this article, we reviewed the expres-sion patterns of HE4 in various malignant neoplasms and its clinical application progress.关键词
人附睾蛋白 4/卵巢癌/子宫内膜癌/肿瘤标志物Key words
HE4/Ovarian cancer/Endometrial cancer/Tumor maker分类
医药卫生引用本文复制引用
唐雨曦,罗晨辉,王瑛,王静..人附睾蛋白4（HE4）在恶性肿瘤中的表达与临床进展[J].肿瘤药学,2015,(2):87-91,5.基金项目
湖南省科技厅重点项目资助（2013FJ2009）。 （）
