肿瘤药学Issue(2)：116-119,4.DOI:10.3969/j.issn.2095-1264.2015.023
紫杉醇脂质体与顺铂周疗方案同步放疗治疗中晚期宫颈癌的疗效比较
Comparison of the Efficacy of Weekly Paclitaxel Liposome and Cisplatin Chemotherapy Plus Concurrent Radiotherapy in the Treatment of Middle and Advanced Cervical Cancer
曹珍珍 1唐迪红 1夏蛮 1禇超男 1蔡净亭 1杨婷1
作者信息
- 1. 中南大学湘雅医学院附属肿瘤医院 妇瘤四科，湖南 长沙，410006
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy and safety of weekly paclitaxel liposome and cisplatin chemo-therapy plus concurrent radiotherapy in the treatment of middle and advanced cervical cancer. Methods From September 2013 to September 2014, 86 patients with middle and advanced cervical cancer who received concurrent chemoradiotherapy in our hospital were selected. All cases were divided into experimental group and control group according to different chemotherapy regimens during radiation therapy. Patients in experimental group (n=43) received radiotherapy concomitant with weekly pacli-taxel liposome (90 mg·m-2) for 4-6 weeks, while those in control group (n=43) received radiotherapy concomitant with cisplatin (90 mg·m-2) for 4-6 weeks. The clinical efficacy and incidence of adverse reactions were observed and compared between two groups. Results The effective rates were respectively 90.1% and 93% in experimental group and control group, and there was no significant difference (P>0.05). The incidence of leucopenia, nausea & vomit, thrombocytopenia and calvities in experimental group were significantly higher than those in the control group (P<0.05). However, no significant differences were found in the occurrence rates of diarrhea and liver and renal dysfunction between two groups (P>0.05). Conclusions The weekly paclitaxel liposome plus concurrent radiotherapy had equal efficacy to but higher safety than the weekly cisplatin plus concurrent radio-therapy in the treatment of middle and advanced cervical cancer.关键词
紫杉醇脂质体/顺铂/中晚期宫颈癌/临床疗效Key words
Paclitaxel liposome/Cisplatin/Middle and advanced cervical cancer/Efficacy分类
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曹珍珍,唐迪红,夏蛮,禇超男,蔡净亭,杨婷..紫杉醇脂质体与顺铂周疗方案同步放疗治疗中晚期宫颈癌的疗效比较[J].肿瘤药学,2015,(2):116-119,4.
