肿瘤药学Issue(2)：130-133,4.DOI:10.3969/j.issn.2095-1264.2015.026
依达拉奉联合高压氧治疗颅内动脉瘤术后脑血管痉挛的临床疗效
Clinical Effect of Edaravone Combined with HBO on Cerebral Vasospasm after Intracranial Aneurysm Surgery
林俏明 1李嫦娥 1范玉华 2莫俊宁 1梁玉婵1
作者信息
- 1. 肇庆市第一人民医院神经内科，广东 肇庆，526060
- 2. 中山大学附属第一医院神经内科，广东 广州，510080
- 折叠
摘要
Abstract
Objective To observe the clinical effect and safety of edaravone combined with high pressure oxygen (HBO) on cerebral vasospasm (CVS) after intracranial aneurysm surgery. Methods A total of 52 patients who were diagnosed as aneurysmal subarachnoid hemorrhage (aSAH) and underwent surgery between June 2010 and October 2011 in our hospital were selected and randomly divided into the observation group (26 cases) and control group (26 cases). The control group was treated with conven-tional therapy and edaravone, while the observation group was added with HBO on the base of control group. The blood velocity of middle cerebral artery (MCA), incidence rate of CVS, cerebral infarction and death rate were observed and compared between the two groups. Besides, NIHSS was used to evaluate the degree of nervous functional defects and MBI was used to evaluate the activities of daily living. Finally, the incidences of side effects were compared between the two groups. Results After 4 weeks’ treatment, the blood velocity of MCA and incidence rate of CVS in the observation group were significantly lower than those in the control group (P<0.05). The NIHSS score of observation group was obviously lower than that of the control group. The MBI score of the observation group was significantly higher than that of the control group (P<0.05). Moreover, there was no significant difference in the incidence rates of cerebral infarction , side effects and yet death rate between the two groups (P>0.05). Con-clusion Edaravone combined with HBO could more effectively alleviate the cerebral vasospasm, improve neurologic impairment and enhance the activities of daily living of patients after intracranial aneurysm surgery.关键词
依达拉奉/高压氧/颅内动脉瘤/脑血管痉挛Key words
Edaravone/HBO/Cerebral vasospasm/Intracranial aneurysm surgery分类
医药卫生引用本文复制引用
林俏明,李嫦娥,范玉华,莫俊宁,梁玉婵..依达拉奉联合高压氧治疗颅内动脉瘤术后脑血管痉挛的临床疗效[J].肿瘤药学,2015,(2):130-133,4.
