肿瘤药学Issue(2)：134-137,4.DOI:10.3969/j.issn.2095-1264.2015.027
小剂量氯胺酮对子宫颈癌患者围术期炎性细胞因子及术后疼痛的影响
Effects of Low-dose Ketamine on Perioperative Cytokine Response and Postoperative Pain in Cervical Cancer Patients
谢宁 1陈伟业 1吴玲 1邓敏端 2吴爱明2
作者信息
- 1. 广州市天河区妇幼保健院药剂科，广东 广州，510620
- 2. 广州市红十字会医院妇产科，广东 广州，510220
- 折叠
摘要
Abstract
Objective To investigate the effects of low-dose ketamine on perioperative cytokine response and postop-erative pain in cervical cancer patients. Methods A total of 65 patients who underwent cervical cancer surgical procedures were randomized into ketamine group (n=31) and control group (n=34). After induction of general anesthesia, patients in ketamine group received preoperative intravenous ketamine 0.3 mg·kg-1 and then continued intravenous ketamine 4 μg·kg-·min-1 until surgery completed. Patients in control group were given the same volume of saline injection. The levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) from peripheral venous blood were assessed at the time points of before anesthesia induction, 2 hours and 24 hours after operation. Postoperative pain was evaluated us-ing visual analogue scale (VAS) at 2 hours, 24 hours and 48 hours respectively after surgery. Results The levels of TNF-α, IL-6 and IL-8 in both groups increased postoperatively (P<0.05), and the levels of TNF-α, IL-6 and IL-8 in ketamine group were lower than those in the control group at 2 hours and 24 hours after surgery (P<0.05). VAS scores in ketamine group were significantly lower than in control group at 2 hours and 24 hours after surgery (P<0.05). Conclusion Low-dose ketamine can relieve the severity of postoperative pain and regulate the serum levels of cytokine in cervical cancer patients.关键词
氯胺酮/子宫颈癌/细胞因子/术后疼痛Key words
Ketamine/Cervical cancer/Cytokine/Postoperative pain分类
医药卫生引用本文复制引用
谢宁,陈伟业,吴玲,邓敏端,吴爱明..小剂量氯胺酮对子宫颈癌患者围术期炎性细胞因子及术后疼痛的影响[J].肿瘤药学,2015,(2):134-137,4.
