肿瘤药学Issue(3)：174-178,5.DOI:10.3969/j.issn.2095-1264.2015.035
纳米药物载体抗肿瘤多药耐药机制的研究进展
Research Progress of the Mechanisms of Nanotechnology in the Treatment of Multidrug Resistant Tumors
赵金香 1李耀华2
作者信息
- 1. 平凉医学高等专科学校，甘肃 平凉，740000
- 2. 甘肃省中医学院，甘肃 兰州，730000
- 折叠
摘要
Abstract
Multidrug resistance (MDR) is a main reason for the failure of tumor chemotherapy, the development of nanotechnology sheds light on targeted delivery of antitumor drugs. Nanocarriers can not only enhance the sensitivity of tumor cells to chemothera-peutic drugs but also downregulate the invasion and metastasis of tumor. The mechanisms of nanocarriers' anti-tumor effect involve in targeting cancer stem cells to overcome MDR and prevent recurrence, preventing the cross talk between cancer cells and their micro-environment, and modifying the immune response to improve the treatment of MDR cancers. In this review, new research progresses of the mechanisms of multidrug resistance and anti-tumor effects of nanotechnology are reviewed.关键词
肿瘤多药耐药/纳米技术/肿瘤干细胞/肿瘤微环境Key words
Multidrug resistance/Nanotechnology/Cancer stem cells/Tumor microenvironment分类
医药卫生引用本文复制引用
赵金香,李耀华..纳米药物载体抗肿瘤多药耐药机制的研究进展[J].肿瘤药学,2015,(3):174-178,5.
