肿瘤药学Issue(3)：213-217,5.DOI:10.3969/j.issn.2095-1264.2015.043
ADA和LDH联合检测鉴别诊断结核性和淋巴瘤性胸腔积液的临床价值研究
Diagnostic Significance of the Combination Detection of ADA and LDH in Tuberculous and Lymphoma Pleural Effusion
摘要
Abstract
Objective To investigate the significance of the combination detection of the level of adenosine deaminase(ADA) and lactate dehydrogenase(LDH) in pleural effusion in diagnosing tuberculous or lymphoma malignant pleural effusion. Methods The levels of ADA and LDH in pleural effusion were measured via Enzyme-linked immunoassay in 455 patients who were confirmed clinically and pathologically with various benign or malignant pleural effusion. The sensitivity, specificity, positive and negative predictive value of the combined detec-tion of ADA and LDH were respectively analyzed in diagnosing tuberculous or non-tuberculous, lymphoma or non-lymphoma pleural effu-sion. Results The ADA levels in patients with tuberculous pleural effusion (TPE) were statistically higher than in those with non-tuberculous benign pleural effusion (non-TPE) or with non-lymphoma malignant pleural effusion (non-LPE), but significantly lower than in patients with lymphoma pleural effusion (LPE) (P<0.05). The LDH levels were higher in patients with malignant pleural effusion than in those with be-nign pleural effusion (P<0.05). The sensitivity and specificity was respectively 85.5%and 94.0%respectively with the combination of ADA level no 1ess than 40 U·L-1 and LDH level less than 500 U·L-1 in the diagnosis of TPE. While in the diagnosis of LPE, the sensitivity and specificity was respectively 86.4%and 96.3%with the combination of ADA level no 1ess than 40 U·L-1 and LDH level no less than 500 U·L-1. Conclusions The ADA and LDH levels in pleural effusion is clinically helpful to identify the character of effusion. This index combination may improve the accuracy for the diagnosis of TPE and LPE.关键词
腺苷脱氨酶/乳酸脱氢酶/结核性胸腔积液/淋巴瘤性胸腔积液Key words
Adenosine deaminase (ADA)/Lactate dehydrogenase (LDH)/Tuberculous pleural effusion/Lymphoma pleural effusion分类
医药卫生引用本文复制引用
聂华萍,梁伟军,刘胜岗,周丽华,肖春香,周辉..ADA和LDH联合检测鉴别诊断结核性和淋巴瘤性胸腔积液的临床价值研究[J].肿瘤药学,2015,(3):213-217,5.基金项目
湘财社指（2014）30号。 （）
