中国现代医生Issue(14)：138-140,3.
幽门螺杆菌感染与胃食管反流患者夜间酸突破的相关性研究
Study on the correlation of the infection of helicobacter pylori and noc-turnal acid breakthrough for patients with gastroesophageal reflux
黄希1
作者信息
- 1. 深圳市宝安区石岩人民医院内科，广东深圳 518108
- 折叠
摘要
Abstract
Objective To investigate the correlation of the infection of helicobacter pylori (Hp) and nocturnal acid breakthrough (NAB) for patients with gastroesophageal reflux disease (GERD). Methods Patients with GERD who were admitted to our hospital from September 2012 to May 2013 were selected. Hp infection of the patients was tested via rapid urease tests of biopsy of gastric antrum and 14C-urea breath tests. 90 patients with GERD who were tested HP positive were randomly assigned to control group and observation group by digital method, with 45 in each group. The observation group received HP eradication, while the control group was orally administered pantoprazole sodium. Reflux diagnosis questionnaire (RDQ) scores, incidence of NAB and ratio of pH lower than 4.0 from 22 h at night till 8 h next day in the two groups before and after the treatment were compared. Results The incidence rate of NAB in observation group was 62.2%, significantly higher than that of 35.6% in control group, and the difference was statistically significant (P<0.05);There was no significant difference of RDQ scores between the two groups before the treatment (P>0.05); After the treatment, RDQ scores in observation group were (12.43 ±3.79)scores, significantly higher than that of (9.21±2.93) scores in control group, and the difference was statistically significant (P<0.05). Hp infection was positively correlated with NAB(r=0.812, P<0.05). Conclusion Hp infection has a certain effect on reducing the incidence of NAB and shows a significant protective effect on the occurrence and development of GERD.关键词
幽门螺杆菌/胃食管反流病/夜间酸突破Key words
Helicobacter pylori (Hp)/Gastroesophageal reflux disease (GERD)/Nocturnal acid breakthrough (NAB)分类
医药卫生引用本文复制引用
黄希..幽门螺杆菌感染与胃食管反流患者夜间酸突破的相关性研究[J].中国现代医生,2014,(14):138-140,3.
