中国现代医生Issue(18)：48-50,54,4.
舍曲林联合尼莫地平治疗脑卒中后抑郁疗效观察
Effects observed after treatment of stroke depression sertraline nimodip-ine
摘要
Abstract
Objective To investigate the efficacy of sertraline and nimodipine in treatment of stroke depression. Meth-ods Selected diagnosed post-stroke depression in our hospital from January 2011 to January 2013 as observed object. 60 cases of stroke depression were randomly divided into observation group and control group of 30 patients, were treated nutrition brain cells, the control group received sertraline 50~100 mg, observation group added in the nimodip-ine 30 mg / time, 3 times a day, sertraline 50~100mg, the course were 8 weeks. Before and after treatment, HAMD-17 score, the clinical efficacy of adverse reactions after treatment were compared between two groups. Results Before treatment , differences HAMD-17 score of were not statistically significant ( P> 0 . 05 ) , After 2 weeks of treatment , HAMD-17 score the observation group and control group of was significantly lower than before treatment,(P<0.05). Af-ter 4 weeks of treatment, HAMD-17 score of the observation group and control group was significantly lower than be-fore treatment and after 2 weeks of treatment,the difference was significant(P <0.05). After 6 weeks of treatment , the HAMD-17 observation group and control group score reduced than before treatment and after 2 weeks of treatment , reduced significantly than after 4 weeks of treatment, the difference was significant(P <0.05). Total efficiency of obser-vation group was 93.33%, the total efficiency of the control group was 70.00%, the difference of the effect was signifi-cant between two groups(P < 0.05). No case occurred during the observation group therapy anorexia, dry mouth , rash , and its complication rate of 10 % of the observation group , the control group complication rate of 40.00%, the differ-ence was significant between two groups(P < 0.05). Conclusion Sertraline and nimodipine treatment stroke depression has good efficacy, and safety, and it is worthy of promotion and application.关键词
脑卒中后抑郁/舍曲林/尼莫地平Key words
Poststroke depression/Sertraline/Nimodipine分类
医药卫生引用本文复制引用
谈鹰,钮富荣..舍曲林联合尼莫地平治疗脑卒中后抑郁疗效观察[J].中国现代医生,2014,(18):48-50,54,4.基金项目
浙江省级公益性技术应用研究计划项目 （）
