中国现代医生Issue(23)：1-3,3.
MTHFD1基因多态性与大肠癌遗传易感性的研究
Research of MTHFD1 gene polymorphism with genetic susceptibility to colorectal cancer
摘要
Abstract
Objective To explore the correlation of MTHFD1 gene polymorphism with genetic susceptibility to colorec-tal cancer. Methods Ninety-six cases of colorectal cancer patients and 96 cases of healthy controls were investigated by questionnaire, the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) detection method was applied. Results Compared with normal control group, MTHFD1 G1958A polymorphism rs2236225 locus allele frequencies of patients with colorectal cancer had significant difference(P<0.05);rs2236225 genotype risk of col-orectal cancer increased 1.6 times(OR=1.603, 95%CI=0.331~2.534, P<0.05). Conclusion MTHFD1 gene polymorphism is closely related to the susceptibility of colorectal cancer, the main course of colorectal cancer is the rs2236225 gen changes in G1958A site of MTHFD1.关键词
亚甲基四氢/叶酸脱氢酶/基因多态性/大肠癌/易感性Key words
Methylenetetrahydrofolate/Folic acid dehydrogenase/Gene polymorphism/Colorectal cancer/Susceptibility分类
医药卫生引用本文复制引用
彭勇,崔建华,赵新华,张石峰,张喜梅,黎亚芳,吴琼辉..MTHFD1基因多态性与大肠癌遗传易感性的研究[J].中国现代医生,2014,(23):1-3,3.基金项目
湖南中医药大学校级青年教师科研基金 （）
