中国现代医生Issue(24)：31-33,36,4.
乌司他丁早期干预多发伤患者全身炎症反应综合征的临床观察
The study of earlier using ulinastatin to influence on SIRS of patients with multi-injure
摘要
Abstract
Objective To evaluate the effect of earlier using ulinastatin for SIRS of patients with multi-injure. Methods A total of 71 patients with multi-injure were divided into two groups:the inspecting group and control group. 37,34 cas-es respectively. The two groups were treated according to the therapy guidelines of multi-injure.Besides taking the ma-noeuvres same as the contrast group, the inspecting group were added ulinastatin for 5 days;The blood concentration of inflammatory factors included Tumor necrosis factor-alpha (TNF-α), Interleukin-6 (IL-6), Interleukin-8 (IL-8) were measured. The days in ICU, the avarege days of stay hospital and the 28-day fatality rate were compared. Results During the first 24 h, the level of inflammatory factors in plasma of the inspecting group elevated, and after that time they decreased continuously. In control group, the level of inflammatory factors in plasma were increased continuously in the every measure times, and had a significont difference between the two groups(P<0.05). The days in ICU, the av-erage days of stay hospital of inspecting group were shorter than that of the contrast group(P<0.05). But the 28-day fa-tality rate didn’t have significant difference in the two groups (P>0.05).Conclusion Using ulinastatin could alleviated SIRS of patients with multi-injure, and can decrease the days in ICU and the average day of stay hospital. But it can not change the 28-day fatality rate.关键词
多发伤/乌司他丁/炎症因子Key words
Multi-injure/Ulinastatin/Inflammatory factor分类
医药卫生引用本文复制引用
张峰海,武卫,洪伟力,郑旭东..乌司他丁早期干预多发伤患者全身炎症反应综合征的临床观察[J].中国现代医生,2014,(24):31-33,36,4.基金项目
卫生部卫生公益性行业科研专项课题（201002014）；浙江省瑞安市科技局资助课题 （）
